Description

Tesa Peptide

Tesa is a synthetic polypeptide composed of 44 amino acids analogous to growth hormone-releasing hormone. The N-terminus of the compound has been modified compared to growth hormone-releasing hormone, the modification of which researchers suggest may lead to improved stability. (1)

Tesa has been studied for its potential mechanism of action. It is thought to interact with growth hormone-releasing hormone (GHRH) receptors in the anterior pituitary gland. This interaction may lead to increased production and secretion of growth hormones.

Growth hormones may act on several cells, including hepatocytes, stimulating the systemic synthesis of insulin-like growth factor-1 (IGF-1). In addition, growth hormone may also stimulate IGF-1 production locally, inside various tissues. (1)

At Pepsynth Labs, we offer Tesa (5mg/20mg) as a peptide that interacts with growth hormone pathways in research settings. Our work focuses on potential mechanisms, amino acid structure, and analytical purity standards that guide Tesa studies in controlled settings.

Overview

IGF-1 has been posited to be the main anabolic mediator of growth hormone, potentially working to stimulate growth and inhibit programmed cell death. (1) On the other hand, growth hormone itself is suggested to be lipolytic, inducing fat breakdown at specific adipose depots, such as abdominal and visceral fat depositions.

Tesa appears to stimulate the release of growth hormone. Consequently, it may also increase IGF-1 levels by interacting with the GHRH receptors in anterior pituitary gland cells.

When Tesa interacts with the GHRH receptor, it is hypothesized that this interaction might alter the receptor’s structure, potentially initiating communication pathways within the cell. It is also theorized that Tesa might enhance the production of cyclic adenosine monophosphate (cAMP) in certain cells.

This process may occur through the stimulation of adenylate cyclase, an enzyme that converts adenosine triphosphate (ATP) into cAMP. Increased cAMP levels may lead to the activation of protein kinase A (PKA), an enzyme deemed critical for transmitting signals within cells. Activated PKA may phosphorylate various target proteins, triggering a cascade of cellular responses. The conjectural stimulation of the GHRH receptor by Tesa and the cAMP-PKA signaling pathway might promote the secretion and distribution of growth hormone (hGH) from somatotroph cells in the pituitary gland.

Research indicates that this peptide may lead to an estimated 69% increase in overall growth hormone levels, measured by the area under the curve (AUC), and a reported 55% increase in the mean pulse area of the growth hormone. However, it does not seem to influence the frequency or peak levels of growth hormone pulses. Additionally, IGF-1 levels apparently surged by 122%.(3)

The N-terminus and C-terminus of the GHRH molecule are altered in Tesa. This potentially lends stability to the peptide and possibly increasing the compound’s resistance to enzyme deactivation compared to natural GHRH. (4) Focusing on the specific alterations, the C-terminus of Tesa is modified by the addition of a trans-3-hexenoic acid group.

This particular change, often referred to as an omega-amino acid modification, is believed to potentially reinforce the peptide’s defense against enzymatic breakdown. On the other end, the N-terminus is modified by the attachment of an acetyl group, represented by the chemical notation CH₃CO-.

This acetylation might enhance not only the molecule’s stability but also its biological activity. As a result of these specific modifications, Tesa is designated chemically as N-(trans-3-hexenoyl)-[Tyr1]hGRF(1–44)NH2 acetate, highlighting the specific alterations made to the peptide.

Chemical Makeup

Molecular Formula: C221H366N72O67S
Molecular Weight: 5136 g/mol
Other Known Titles: (3E)-hex-3-enoylsomatoliberin

Research and Clinical Studies

Tesa Peptide and Lipodystrophy

Lipodystrophy models refer to abnormal or pathological fat distribution and metabolism. The primary feature of lipodystrophy is the irregular distribution of fat into depots. This leads to loss of fat (lipoatrophy) from specific areas, and accumulation of excess fat (lipohypertrophy) in other regions. This abnormal fat distribution is often associated with serious negative metabolic changes, including insulin resistance, elevated cholesterol, and triglyceride levels.

Test models exhibiting lipodystrophy report low levels of GH and IGF-1. Researchers studying Tesa action and potential impact suggest that the peptide may positively influence lipid metabolism, especially in lipodystrophy models.

For example, two phase III studies(6) were conducted with 806 test subjects over 26 weeks, followed by another 26-week extension. Each of the 806 test subjects had immunodeficiencies and lipodystrophy. The subjects were divided into two groups; one group with 543 subjects was presented with Tesa, and the remaining 263 subjects were presented with a placebo for 26 weeks.

After this duration, the Tesa subjects were again randomly divided into two groups, in which one group continued Tesa treatment, and the other half was presented with a placebo for another 26 weeks. At week 26, the researchers observed a significant decrease in visceral adipose tissue level amongst the Tesa subjects, at least 15.4%.

Additionally, the levels of triglyceride and cholesterol were reported to have significantly decreased compared to the placebo group.

Tesa Peptide and Immunodeficient Fat Fractions

Researchers posit that serious immunodeficiencies may induce non-alcoholic fatty liver disease (NAFLD), which in clinical cases is reported in nearly 40% of HIV-positive test models. (7) In this study,(5) 61 test subjects with HIV and a high hepatic fat fraction (HFF) were selected as test models. These subjects were administered Tesa or a placebo for 12 months.

The HFF rate was measured at the conclusion of the study. After 12 months, researchers reported that 35% of subjects receiving Tesa showed a reduction in HFF of up to 5%, while only 4% of subjects in the placebo group experienced any HFF decrease. Glucose levels remained unchanged throughout the study.

Tesa Peptide and Cognition

In this clinical study, (8) immunodeficient models with mild cognitive impairment were observed. The main intent of this study was to determine Tesa potential effect on neurological functioning. 100 subjects, aged more than 40 years, participated in this trial and underwent Tesa daily for 6 months, followed by the absence of Tesa influence for the next 6 months.

Then Tesa was reintroduced once a day for another 6 months. The primary outcome of this study was reported in changes in neurocognitive performance measured by the Global Deficit Score (GDS) after 6 and 12 months. This study is underway, and the final results have not been published.

Tesa Peptide and Insulin

The primary goal of this study (9) was to evaluate the potential effects of Tesa on insulin sensitivity. A total of 53 participants with Type II diabetes took part in a 12-week randomized clinical trial. Participants were divided into three groups, receiving either a low dose or high dose of Tesa, or a placebo.

Following the study period of 12 weeks, the concentration of fasting glucose, glycosylated hemoglobin, and diabetes control was measured. There was no reported significant reduction in either of these parameters. The results of all three groups appeared to be indifferent.

Tesa Peptide and Muscle Tissue

In a research investigation, the possible impacts of Tesa on the structural quality of muscle tissues were evaluated using computed tomography (CT) scans. (10) Computed tomography (CT) is an imaging tool that combines X-rays and computer technology to produce detailed pictures of internal structures.

The findings from this study tentatively suggested a potential association between Tesa and improvements in the density and overall volume of muscle tissues.

It was observed that specific muscle groups, particularly the rectus abdominis, psoas major, and paraspinal muscles, exhibited more noticeable variations. These variations consisted of either increased muscle density and volume or decreased fat within the muscle tissue.

From a statistical perspective, the changes in muscle density and size in these specific muscles were significantly different compared to the control group. The reduction in fat content within these muscles also showed significant differences when compared to results from the placebo group.

Tesa Peptide and Visceral Fat

Visceral obesity involves the accumulation of excess fat around and within internal organs, a condition often observed in models of lipodystrophy – a disorder characterized by abnormal distribution of fat cells. This form of excessive fat accumulation is potentially linked to several metabolic issues. These issues include insulin resistance, a diminished ability to respond to insulin, leading to elevated blood glucose levels.

Furthermore, visceral obesity is associated with the development of atherosclerosis, a condition where plaque builds up in the arteries. It is also linked to elevated levels of low-density lipoprotein (LDL) cholesterol and hyperuricemia, which is an excess of uric acid. The significance of these models extends beyond aesthetic concerns, indicating that lipodystrophy may precipitate profound metabolic disturbances.

In addressing these challenges, Tesa, a synthetic form of the growth-hormone-releasing factor, has been proposed as a possible positive avenue for further development. Research into Tesa has suggested it may lead to a reduction of up to 25% in visceral fat among lipodystrophy models. (11)

Tesa peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.

Research-Focused Tesa Synthesis and Availability

Tesa (5mg/20mg) is for controlled laboratory research in studies of the growth hormone and IGF-1 pathways. Our peptide catalog includes custom peptide manufacturing and high-purity peptide compounds. Read about our approach that supports advanced research standards for studies of the metabolic and GHRH receptors.

We maintain advanced custom peptide manufacturing services and high-purity peptide compounds at Pepsynth Labs to support research focused on metabolic pathways, synthetic peptide structure, and analytical peptide evaluation.

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