BAM15 50mg Capsules (30ct) – Next-Generation Metabolic Research Compound

Take your cellular bioenergetics and metabolic studies to the cutting edge with our premium BAM15 50mg capsules. BAM15 (N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine) is a highly selective mitochondrial protonophore uncoupler that disrupts the coupling between nutrient oxidation and ATP synthesis. By allowing protons to bypass ATP synthase across the inner mitochondrial membrane, it forces cells to burn substrate at an accelerated rate to meet energy demands.

Whether your focus is anti-aging pathways, insulin resistance models, obesity research, or advanced athletic bioenergetics, BAM15 offers an unparalleled mechanism of action with vastly superior safety parameters compared to classic uncoupling agents like DNP or FCCP.

Key Benefits & Research Mechanisms

• Targeted Mitochondrial Uncoupling: Efficiently uncouples oxidative phosphorylation (OXPHOS) to stimulate cellular respiration and oxygen consumption rate (OCR).

• Zero Plasma Membrane Depolarization: Maintains cell viability by selectively targeting the inner mitochondrial membrane without altering the electrical potential of the plasma membrane.

• Enhanced Energy Expenditure: Triggers upstream signaling pathways like AMPK and PGC-1α, driving rapid fatty acid oxidation and mitochondrial biogenesis.

• Reduced Cytotoxicity: Demonstrates a significantly broader and safer dosing range in experimental models than traditional protonophores.

• Optimal Oral Bioavailability: Delivered in a convenient 50mg capsule format, ensuring precise dosing and excellent tissue distribution for in vivo evaluation.

The Science: Why BAM15 Changes the Game

In mitochondrial biology, maintaining a delicate balance between energy production and reactive oxygen species (ROS) is critical. BAM15 exhibits an $EC_{50}$ of 270 nM in myoblast mitochondria, effectively sustaining uncoupled respiration across a wide concentration spectrum.

Because it does not cause toxic intracellular swelling or cell membrane leakage, it allows researchers to study the therapeutic benefits of high metabolic expenditure—such as fat loss, glycemic control, and tissue protection from ischemic injury—without the standard toxicities associated with older-generation metabolic uncouplers.

Product Specifications

Storage & Handling Guidelines

Keep tightly sealed in a cool, dry place away from direct sunlight. Ideal storage temperature is between 15°C and 25°C. This product is intended strictly for laboratory research and development use. Not for direct human or veterinary administration.